This 10-story urban structure accommodates three different disciplines, University at Buffalo, Kaleida Health and Jacobs Research Institute, while facilitating the rapid changes each is currently undergoing. Yazdani Studio of CannonDesign led the process of bringing 3 institutions together and developing a physical space that could create synergistic thinking. The design accommodates the sometimes conflicting functional needs of 4 different cultures in one high-performance facility – translational research, education, business, and clinical care. The building offers space for patient care and research labs as well as a prototype fabrication, research funding specialists, and research publication. Integrating three clients and evolving disciplines into one building necessitated an adaptable building. Isolating the building core to one side of the floor plate maximizes flexibility by creating unfettered real estate. Program elements common to each client were collocated, encouraging collaboration and the sharing of ideas. To support the goal of being a “100 year building,” the structure utilizes a planning module for healthcare facilities that can be readily adapted from one type of facility to a radically different type, facilitating expansion, and accommodation of future technologies and conversion of building zones to entirely different functions